John S. Torday

Evolutionary Biology, Cell-Cell Communication and Complex Disease

An integrative view of the evolution of genetics and the natural world. Even in this advanced age of genomics, the evolutionary process of unicellular and multicellular organisms is continually in debate. Evolutionary Biology, Cell–Cell Communication, and Complex Disease challenges current wisdom by using physiology to present an integrative view of the nature, origins, and evolution of fundamental biological systems.Providing a deeper understanding of the way genes relate to the traits of living organisms, this book offers useful information applying evolutionary biology, functional genomics, and cell communication studies to complex disease. Examining the 4.5 billion-year evolution process from environment adaptations to cell-cell communication to communication of genetic information for reproduction, Evolutionary Biology hones in on the “why and how” of evolution by uniquely focusing on the cell as the smallest unit of biologic structure and function.”
Evolution, The Logic of Biology

By focusing on the cellular mechanisms that underlie ontogeny, phylogeny and regeneration of complex physiologic traits, Evolution, the Logic of Biology demonstrates the use of homeostasis, the fundamental principle of physiology and medicine, as the unifying mechanism for evolution as all of biology. The homeostasis principle can be used to understand how environmental stressors have affected physiologic mechanisms to generate condition-specific novelty through cellular mechanisms.

Evolution, the Logic of Biology allows the reader to understand the vertebrate life-cycle as an intergenerational continuum in support of effective, on-going environmental adaptation. By understanding the principles of physiology from their fundamental unicellular origins, culminating in modern-day metazoans, the reader as student, researcher or practitioner will be encouraged to think in terms of the prevention of disease, rather than in the treatment of disease as the eradication of symptoms.

By tracing the ontogeny and phylogeny of this and other phenotypic homologies, one can perceive and understand how complex physiologic traits have mechanistically evolved from their simpler ancestral and developmental origins as cellular structures and functions, providing a logic of biology for the first time.

Evolution, the Logic of Biology will be an invaluable resource for graduate students and researchers studying evolutionary development, medicine and biology, anthropology, comparative and developmental biology, genetics and genomics, and physiology.
Evidence-Based Evolutionary Medicine

A groundbreaking, evidence-based text to the growing field of evolutionary medicine Evidence-Based Evolutionary Medicine offers a comprehensive review of the burgeoning field of evolutionary medicine and explores vital topics such as evolution, ecology, and aging as they relate to mainstream medicine.
More books

1. Torday JS, Rehan VK. Evolutionary Biology, Cell-Cell Communication and Complex Disease. Wiley-Blackwell (Feb 14,2012).

2. Torday, J.S., Blackstone, N., Rehan, V.K. 2014. Evidence-Based Evolutionary Medicine.

3. Torday JS, Rehan VK. Evolution, The Logic of Biology. Wiley, Hoboken, 2017.

4. Torday JS, Blackstone N, Rehan VK. Evidence-Based Evolutionary Medicine. Wiley, Hoboken, 2018.

5. Torday JS, Miller WB Jr. Cellular-Molecular Approach to Evolution. Springer, 2020.

6. Guex J, Torday JS, Miller WB Jr. Morphogenesis, Environmental Stress and Reverse Evolution. Springer, 2020.

7. Torday JS and Miller WB Jr. The Singularity of Nature. Royal Chemical Society, 2020.

8. Torday JS and Miller WB Jr. Cellular-Molecular Mechanisms in Epigenetic Evolutionary Medicine. Springer, 2020.

9. Torday JS. Hormones and Reality. Springer Nature. 2021.

10. Torday JS., Quantum Mechanics, Cell-Cell Signaling and Evolution. Elsevier (2022).

11. Torday JS., Consciousness-based Evolution. CRC Press.(December, 2023)

12. Torday JS., Sacco, R., Energy and Evolution. Springer Nature…Submitted September 18, 2024.

13. Torday JS., Sacco, R.G. The Evolution of Consciousness- an Inside-out/Outside-in Approach…Proposal sent to Springer 2/6/2024. Contract for June 2026 submission signed on April 30, 2024.

Evolutionary biology redux.

Perspect Biol Med. 2013;56(4):455-84.

Abstract

This article offers a novel, enlightened concept for determining the mechanism of evolution. It is based on homeostasis, which distinguishes life from non-life and as such is the universal mechanism for the evolution of all living organisms. This view of evolution is logical, mechanistic, non-scalar, predictive, testable, and falsifiable, and it illuminates the epistemological relationships between physics and biology, ontogeny and phylogeny, development and aging, ultimate and proximate causation, health and disease. In addition to validating Haeckel’s biogenetic law and Lamarckian epigenetics, reflecting the enabling value of the cellular approach, this perspective also expresses the evolutionary process at the cell-molecular level, since the mechanism of cell communication itself is universal in biology, in keeping with a Kuhnian paradigm shift. This approach may even elucidate the nature and evolution of consciousness as a manifestation of the cellular continuum from unicellular to multicellular life. We need such a functional genomic mechanism for the process of evolution if we are to make progress in biology and medicine. Like Copernican heliocentrism, a cellular approach to evolution may fundamentally change humankind’s perceptions about our place in the universe.
Complete list of publications on Google Scholar

For complete list of publications on Google scholar, click here.

Departments of Pediatrics and Ob/Gyn, Evolutionary Medicine Program, David Geffen School of Medicine; University of California- Los Angeles

Quote

Books

Evolutionary Biology, Cell-Cell Communication and Complex Disease

Evolution, The Logic of Biology

Evidence-Based Evolutionary Medicine

More books

Publications

Evolutionary biology redux.

Complete list of publications on Google Scholar

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