William B. Miller, Jr.

William Miller has a B.S. in Medicine at Northwestern University in Biology and attended Northwestern Medical School, participating in their six-year medical program. He is a member of the medical honor society Alpha Omega Alpha.

Miller's investigation of evolutionary mechanisms began with a chance encounter with Sue, the extraordinary Tyrannosaurus Rex skeleton housed in the magnificent rotunda of the Chicago Field Museum. Nothing he had previously read about evolutionary mechanisms conformed to the presence of the specific anatomic features that specimen demonstrated.

His work has focused on the impact of the microbiome on biological and evolutionary development, basal cellular cognition/sentience, the intelligent, measuring cell, the ambiguity of biological information, individual and collective cellular information fields, the senome, and the recently introduced novel concepts of natural viral-celluar engineering and cognitive selection.

He has published widely in evolutionary biology, including multiple books, book chapters, and over 50 peer-reviewed scientific articles.

Cognition-Based Evolution: Natural Cellular Engineering and the Intelligent Cell

Cognition-Based Evolution is the first comprehensive alternative to 20th-century NeoDarwinism, proposing a radical 21st-century evolutionary framework with a novel point of origination: all cells are intelligent and must measure uncertain environmental information to sustain themselves. In Cognition-Based Evolution, life is defined by cognition. From this differential stance, evolutionary biology transforms into the science of why, how, what, and with whom cells measure and communicate under stressful environmental conditions. Life’s context is uncertain environmental information, communication is its means, and genes are its tools. Evolution is its yield as continuous non-random self-referential cellular problem-solving.
Bioverse

For as long as humans have been on Earth, we have looked to the stars to find answers to the secrets the universe. Miller suggests that we may find more meaningful solutions at the end of a microscope rather than a telescope. Bioverse explores the wonders of the perpetual partnership between our personal cells and the microbial world, resulting in an entirely new view of our living planet.

To understand life in all its varieties, we must undertake to understand our cells. While the partnership between our cells and our microbes has largely been thought of as that of “host” and “guest,” Miller reveals the true terms of partnership under which both our microbial fraction and our personal cells conduct a life-long dialogue, redefining our traditional conceptions of intelligence and problem-solving. This radical new approach explains exactly how our human choices are centered within the same cellular rules that enable our cells to seamlessly sustain our lives.

We are now entering the “Era of the Cell,” a time in history during which medical and scientific innovations have spurred growth far beyond ever imagined by our ancestors. For the first time, we are not only building machines to enhance our lives but engineering living organisms to assist our futures. From the biological origins of evolution to the invention of the compound microscope by a Dutch lens maker in the 17th century, new research reveals the surprising links between our microbiome, our metabolism, and physiology, contributing to every facet, including our moods and behaviors. Miller introduces readers to a greater understanding of our impact on the planet and the environment’s reciprocal impact on each of us.

By exploring the extent of our deeply integrated cellular world, Bioverse provides profound insights about ourselves, our health and well-being, our social systems, and our permanent relationship with the planet and the cosmos.
More books

Miller Jr WB. 2013. The Microcosm Within: Evolution and Extinction in the Hologenome. Universal-Publishers.

Torday, JS. Miller Jr, WB., 2020. Cellular-Molecular Mechanisms in Epigenetic Evolutionary Biology. Springer Nature: Cham, Switzerland.

Guex, J, Torday JS, Miller, Jr. WB. (eds) 2020. Morphogenesis, Environmental Stress and Reverse Evolution. Springer.

Torday J and Miller Jr., W. 2020. The Singularity of Nature. London: Royal Society of Chemistry.

Reber, A.S., Baluška, F. Miller, W.B. Jr. 2023. The Sentient Cell: The Cellular Foundations of Consciousness. Oxford, UK: Oxford University Press

Miller, W.B. Jr., Baluška, F, Reber, A.S., Slijepčević, P. Cognition-Based Biology: Cellular Sentience, Communication, and Symbiosis. Springer. In preparation: Dec. 2025.

Selected Publications

Miller, WB. 2016 Cognition, Information Fields and Hologenomic Entanglement: Evolution in Light and Shadow. Biology 5, 21. https://doi.org/10.3390/biology5020021

Miller Jr, WB. 2018 Biological information systems: Evolution as cognition-based information management. Progress in Biophysics and Molecular Biology. 134, 1-26. https://doi.org/10.1016/j.pbiomolbio.2017.11.005

Baluška F, Miller, Jr. WB 2018 Senomic View of the Cell: Senome versus Genome.Communicative and Integrative Biology 11: 1-9. https://doi.org/10.1080/19420889.2018.1489184

Miller WB, Baluška F. Torday JS. 2020. Cellular Senomic Measurements in Cognition-Based Evolution. Progress in Biophysics and Molecular Biology. 156, 20-33. https://doi.org/10.1016/j.pbiomolbio.2020.07.002

Miller WB, Torday JS, Baluška F. 2020. The N-Space Episenome Unifies Cellular Information Space-Time within Cognition-Based Evolution. Progress Biophysics and Molecular Biology. 150, 112-139. https://doi.org/10.1016/j.pbiomolbio.2019.08.006

Miller W B Jr, Reber A S, Marshall P & Baluška F (2023) Cellular and Natural Viral Engineering in Cognition-Based Evolution. Communicative & Integrative Biology, 16:1, 2196145. https://doi.org/10.1080/19420889.2023.2196145.

Miller Jr, W. B. (2023). A scale-free universal relational information matrix (N-space) reconciles the information problem: N-space as the fabric of reality. Communicative & Integrative Biology, 16(1), 2193006. https://doi.org/10.1080/19420889.2023.2193006

Miller Jr. W.B. Baluška, F., & Reber, A. S. (2023). A revised central dogma for the 21st century: all biology is cognitive information processing. Progress in Biophysics and Molecular Biology. 182: 34-48. https://doi.org/10.1016/j.pbiomolbio.2023.05.005

Reber, A. S., Miller Jr, W. B., Slijepcevic, P., & Baluška, F. (2024). The CBC theory and its entailments: Why current models of the origin of consciousness fail. EMBO reports, 25(1), 8-12. https://doi.org/10.1038/s44319-023-00004-6

Miller Jr, W. B., Baluška, F., Reber, A. S., & Slijepčević, P. (2024). Biology in the 21st Century: Natural Selection is Cognitive Selection. Progress in Biophysics and Molecular Biology. 190:170-184. https://doi.org/10.1016/j.pbiomolbio.2024.05.001
Complete List of Publications

For complete list of publications, click here.

Banner Health Systems (emeritus); Independent Researcher/Bioverse Foundation

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Books

Cognition-Based Evolution: Natural Cellular Engineering and the Intelligent Cell

Bioverse

More books

Publications

Selected Publications

Complete List of Publications

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